Bilamellar Cationic Liposomes Protect Adenovectors from Preexisting Humoral Immune Responses
نویسندگان
چکیده
منابع مشابه
The Effect of Cationic Liposomes Encapsulating pcDNA3.1+PA Plasmids on Humoral Immune Response in Mice
Background: DNA vaccines are third generation vaccines which have made promises to combat infectious diseases. Cationic liposomes are used as effective delivery systems for DNA vaccines to generate stronger immunity. Objective: Encapsulation of pcDNA3.1+PA plasmid, encoding protective antigen (PA) of Bacillus anthracis (B. anthracis) into cationic liposomes, and evaluation of its effect on spec...
متن کاملthe effect of cationic liposomes encapsulating pcdna3.1+pa plasmids on humoral immune response in mice
background: dna vaccines are third generation vaccines which have made promises to combat infectious diseases. cationic liposomes are used as effective delivery systems for dna vaccines to generate stronger immunity. objective: encapsulation of pcdna3.1+pa plasmid, encoding protective antigen (pa) of bacillus anthracis (b. anthracis) into cationic liposomes, and evaluation of its effect on spec...
متن کاملThe effect of cationic liposomes encapsulating pcDNA3.1+PA plasmids on humoral immune response in mice.
BACKGROUND DNA vaccines are third generation vaccines which have made promises to combat infectious diseases. Cationic liposomes are used as effective delivery systems for DNA vaccines to generate stronger immunity. OBJECTIVE Encapsulation of pcDNA3.1+PA plasmid, encoding protective antigen (PA) of Bacillus anthracis (B. anthracis) into cationic liposomes, and evaluation of its effect on spec...
متن کاملCharacterization of Immune Responses Induced by Combined Clade-A HIV-1 Recombinant Adenovectors in Mice
Background: Numerous evidences indicate that in some HIV-1 positive patients, the humoral and cellular immune responses are induced against HIV-1 proteins and this is inversely related to the progress of infection. Objective: The aim of this study was the evaluation of the Adenovectors containing HIV genes in induction of immune responses in mice. Methods: The HIV-1 genes including gag p24, rev...
متن کاملSmall Cationic DDA:TDB Liposomes as Protein Vaccine Adjuvants Obviate the Need for TLR Agonists in Inducing Cellular and Humoral Responses
Most subunit vaccines require adjuvants in order to induce protective immune responses to the targeted pathogen. However, many of the potent immunogenic adjuvants display unacceptable local or systemic reactogenicity. Liposomes are spherical vesicles consisting of single (unilamellar) or multiple (multilamellar) phospholipid bi-layers. The lipid membranes are interleaved with an aqueous buffer,...
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ژورنال
عنوان ژورنال: Molecular Therapy
سال: 2002
ISSN: 1525-0016
DOI: 10.1006/mthe.2002.0545